All content on this site is intended for healthcare professionals only. By acknowledging this message and accessing the information on this website you are confirming that you are a Healthcare Professional. If you are a patient or carer, please visit the International Myeloma Foundation
The nuclear receptors (NRs) are a family of transcription factors that are regulated by steroids and related hormones, such as vitamin D3, thyroid hormone, and retinoids. NRs are good drug targets with internal pockets receptive to hydrophobic, drug-like molecules and well-characterized mechanisms that direct transcriptional coregulators to promoter elements.