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How to sequence BCMA-directed therapies in early relapsed/ refractory multiple myeloma
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Symposium | The next wave of immune-based therapies: What you need to know in relapsed/refractory multiple myeloma
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During the European Hematology Association (EHA) 2024 Hybrid Congress, the Lymphoma Hub and Multiple Myeloma Hub held a joint satellite symposium entitled: Sequencing immune-based therapies in B-cell malignancies. Here the Multiple Myeloma Hub is pleased to share the session: Next wave of immune-based therapies: What you need to know, which focused on relapsed/refractory (R/R) multiple myeloma (MM) and was presented by Krina Patel, MD Anderson Cancer Center, Houston, US.
Symposium | The next wave of immune-based therapies: What you need to know in relapsed/refractory multiple myeloma
Listen to the podcast here:
Symposium | The next wave of immune-based therapies: What you need to know in relapsed/refractory multiple myeloma
In this presentation, Patel discusses novel targets and therapies for multiple myeloma, such as cereblon E3 ligase modulators (CELMoDs), bispecific antibodies targeting FcRH5, trispecific antibodies, and G protein-coupled receptor class C group 5 member D (GPRC5D)-targeted chimeric antigen receptor (CAR) T-cell therapies. Patel also provides an overview of key ongoing trials of immunotherapy combinations for the treatment of MM (Table 1).
Table 1. Key ongoing clinical trials of combination therapies in R/R MM*
|
NCT number |
Phase |
Aim |
|---|---|---|
|
NCT05850234† |
Ib/II |
To evaluate the safety, tolerability, pharmacokinetic characteristics, pharmacodynamic effect, and immunogenicity of GC012F in subjects with R/R MM and determine the recommended phase II dose. |
|
NCT05509530‡ |
II |
To evaluate the safety and efficacy of anti-BCMA/GPRC5D CAR Tcell therapy in treating R/R MM. |
|
NCT06121843§ |
I |
To evaluate the safety, effectiveness, and tolerable dose of BMS986393 in novel combinations in participants with R/R MM. |
|
BCMA, B-cell maturation antigen; CAR, chimeric antigen receptor; GPRC5D, G protein-coupled receptor class C group 5 member D; MM, multiple myeloma; R/R, relapsed/refractory. *Adapted from Clinicaltrials.gov. |
||
Watch or download the presentation to learn more about:
-
Clinical outcomes for novel immunomodulatory drugs in R/R MM
-
Key ongoing pivotal trials for CAR T-cell therapy, including:
-
Phase II QUINTESSENTIAL trial of CA0881000, a GPRC5D-directed CAR T-cell therapy in R/R MM
-
Phase III CARTITUDE-5 trial of bortezomib, lenalidomide, and dexamethasone followed by ciltacabtagene autoleucel in newly diagnosed MM for whom allogeneic stem cell transplant is not planned as initial therapy
-
Phase III KarMMa-9 trial of idecabtagene vicleucel with lenalidomide maintenance therapy versus lenalidomide maintenance therapy alone in adult participants with newly diagnosed MM who have suboptimal response after autologous stem cell transplantation
-
Phase I/II OriCAR-017-US-PI open-label, single-arm, multicenter trial of OriCAR-017 in MM
-
Key novel data for MM treatments presented at EHA 2024
Key points
-
Following B-cell maturation antigen (BCMA) therapy, new targets for bispecifics and CAR T cells may facilitate better outcomes; however, additional information is required to determine optimal sequencing and/or combinations.
-
It is imperative to optimize supportive care and preventive measures for infections, deep vein thrombosis, gastrointestinal disorders, and other toxicities.
-
Biomarkers have the potential to significantly improve clinical decision-making; more research is needed to determine the mechanisms of resistance for these novel immunotherapies.
Q&A
This symposium closed with a panel Q&A session with live audience participation, where our panelists shared their perspectives on the next wave of immune-based therapies in R/R MM.
Q&A | Next wave of immune-based therapies in relapsed/refractory multiple myeloma
This independent educational activity was supported by Bristol Myers Squibb. All content was developed independently by the faculty.
- Clinicaltrials.gov. NCT05850234. https://clinicaltrials.gov/study/NCT05850234. Updated July 18, 2024. Accessed Jul 13, 2024.
- Clinicaltrials.gov. NCT05850234. https://clinicaltrials.gov/study/NCT05509530. Updated August 22, 2022. Accessed Jul 13, 2024.
- Clinicaltrials.gov. NCT06121843. https://clinicaltrials.gov/study/NCT06121843. Updated May 28, 2024. Accessed Jul 13, 2024.
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