The mm Hub website uses a third-party service provided by Google that dynamically translates web content. Translations are machine generated, so may not be an exact or complete translation, and the mm Hub cannot guarantee the accuracy of translated content. The mm and its employees will not be liable for any direct, indirect, or consequential damages (even if foreseeable) resulting from use of the Google Translate feature. For further support with Google Translate, visit Google Translate Help.
The Multiple Myeloma Hub is an independent medical education platform, sponsored by Bristol Myers Squibb, GSK, Johnson & Johnson, Pfizer, Roche and Sanofi. The levels of sponsorship listed are reflective of the amount of funding given. View funders.
Now you can support HCPs in making informed decisions for their patients
Your contribution helps us continuously deliver expertly curated content to HCPs worldwide. You will also have the opportunity to make a content suggestion for consideration and receive updates on the impact contributions are making to our content.
Find out moreCreate an account and access these new features:
Bookmark content to read later
Select your specific areas of interest
View mm content recommended for you
Test your knowledge! Take our quick quiz before and after you read this article to find out if you improved your knowledge. Results help us to improve content and continually provide open-access education.
Question 1 of 2
Which of the following features have NOT been associated with shortened duration of response with CAR T-cell therapy in multiple myeloma?
A
B
C
D
Video series
During the European Hematology Association (EHA) 2023 Hybrid Congress, the Lymphoma Hub and Multiple Myeloma Hub held a joint satellite session on the ins and outs of CAR T-cells in the real world.
Here the Multiple Myeloma Hub is pleased to share the presentation by Shaji Kumar, Mayo Clinic, Rochester, US, on biomarkers and eligibility for CAR T-cell therapies in multiple myeloma.
In this presentation, Shaji Kumar shares the currently approved CAR T-cell products for MM, discussing their up-to-date clinical data (Figure 1). He also shares the limitations and logistical challenges facing the implementation CAR T-cell therapy, as well as the current eligibility criteria for its use (Figure 2).
Figure 1. Efficacy and safety data for KarMMa and CARITITUDE-1*
AE, adverse event; CR, complete response; CRS, cytokine release syndrome; DoR, duration of response; ICANS, mmune effector cell-associated neurotoxicity syndrome; MRD, minimal residual disease; NR, not reached; ORR, overall response rate; PD, progressive disease; PFS, progression-free survival; OS, overall survival; VGPR, very good partial response.
*Adapted Chekol Abebe, et al.,1 Martin T, et al.,2 and Munshi, et al.3
Figure 2. Eligibility criteria for the use of CAR T-cell products*
CAR, chimeric antigen receptor; ECOG PS, Eastern Cooperative Oncology Group Performance Status; SCT, stem cell transplant.
*Adapted from Dave, et al.4
Watch or download the presentation to learn more about:
This activity was supported through an educational grant from Bristol Myers Squibb.
References