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Masterclass | High-risk smoldering MM: Latest updates for diagnostic criteria and prognosis

By Jennifer Reilly

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Shaji KumarShaji KumarIrene GhobrialIrene GhobrialMaría-Victoria MateosMaría-Victoria Mateos

Oct 10, 2025

Learning objective: After reading this article, learners will be able to cite a new clinical development in high-risk smoldering MM.


The recognition and management of high-risk smoldering multiple myeloma (MM) continues to evolve, with advances in diagnostic criteria and risk stratification informing prognosis and therapeutic decision- -making. 

The Multiple Myeloma Hub spoke with María-Victoria Mateos, Irene Ghobrial, and Shaji Kumar to gain their expert insights on the latest updates to diagnostic criteria, current approaches to risk assessment and prognosis, and the rationale for early intervention in patients with high-risk smoldering MM. 

Evolving diagnostic criteria for high-risk smoldering MM

Evolving diagnostic criteria for high-risk smoldering MM

The Multiple Myeloma Hub spoke with María-Victoria Mateos, University Hospital of Salamanca, Salamanca, ES. We asked about the evolving diagnostic criteria for high-risk smoldering MM.

Risk stratification and prognosis in smoldering MM

Risk stratification and prognosis in smoldering MM

The Multiple Myeloma Hub spoke to Irene Ghobrial, Dana-Farber Cancer Institute, Boston, US. We asked about risk stratification and prognosis in smoldering multiple myeloma.

What is the rationale for early intervention in high-risk smoldering MM?

What is the rationale for early intervention in high-risk smoldering MM?

The Multiple Myeloma Hub spoke with Shaji Kumar, Mayo Clinic, Rochester, US. We asked, What is the rationale for early intervention in high-risk smoldering multiple myeloma?

This educational resource is independently supported by Johnson & Johnson. All content was developed by SES in collaboration with an expert steering committee. Funders were allowed no influence on the content of this resource.

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