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KPd for patients with early RRMM: Primary analysis from the phase II SELECT trial
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The phase II SELECT trial (NCT04191616) assessed the safety and efficacy of once-weekly carfilzomib plus pomalidomide and dexamethasone (KPd) in 52 adult patients with early relapsed/refractory multiple myeloma (RRMM) who were refractory to lenalidomide.1 Results of the primary analysis from this trial were published in Leukemia & Lymphoma by Perrot, et al.1 |
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Although the primary endpoint of overall response rate (ORR) was not met, the ORR was 57.7%, with a median duration of response of 20.3 months, highlighting the potential efficacy of KPd in patients with RRMM who are refractory to lenalidomide. |
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Measurable residual disease (MRD) negativity was achieved in 9.6% of patients, indicating that KPd can effectively reduce MRD to undetectable levels in a subset of patients, a crucial prognostic factor for long-term remission. |
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The median progression-free survival and overall survival among all patients was 11.1 months and 18.8 months, respectively. |
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Treatment-emergent adverse events were consistent with the known safety profiles of carfilzomib and pomalidomide, with no new safety signals identified, suggesting that the KPd regimen is a viable option for heavily pretreated patients. |
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The findings suggest an overall favorable benefit/risk profile of KPd as a salvage therapy for patients with multidrug-resistant RRMM relative to currently available therapies. |
- Perrot A, Delimpasi S, Spanoudakis E, et al. An open-label phase 2 study treating patients with first or second relapse of multiple myeloma with carfilzomib, pomalidomide, and dexamethasone (KPd): SELECT study. Leuk Lymphoma. 2024;65(6):833-842. DOI: 1080/10428194.2024.2322030
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