KPd for patients with early RRMM: Primary analysis from the phase II SELECT trial

Although the primary endpoint of overall response rate (ORR) was not met, the ORR was 57.7%, with a median duration of response of 20.3 months, highlighting the potential efficacy of KPd in patients with RRMM who are refractory to lenalidomide.

Measurable residual disease (MRD) negativity was achieved in 9.6% of patients, indicating that KPd can effectively reduce MRD to undetectable levels in a subset of patients, a crucial prognostic factor for long-term remission​.

The median progression-free survival and overall survival among all patients was 11.1 months and 18.8 months, respectively. 

Treatment-emergent adverse events were consistent with the known safety profiles of carfilzomib and pomalidomide, with no new safety signals identified, suggesting that the KPd regimen is a viable option for heavily pretreated patients.