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2023-11-30T15:51:27.000Z

ASH 2023: Top abstracts in MM and other plasma cell dyscrasias

Nov 30, 2023
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Learning objective: After reading this article, learners will be able to cite a new clinical development in multiple myeloma.

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To help navigate the exciting content being presented at the 65th American Society of Hematology (ASH) Annual Meeting and Exposition, the Multiple Myeloma Hub Steering Committee have provided their recommendations for the top abstracts to look out for in multiple myeloma and other plasma cell dyscrasias.

Newly diagnosed multiple myeloma

4

Results of the phase III randomized Iskia trial: Isatuximab-carfilzomib-lenalidomide-dexamethasone vs carfilzomib-lenalidomide-dexamethasone as pre-transplant induction and post-transplant consolidation in newly diagnosed multiple myeloma patients

Francesca Gay

207

Daratumumab, carfilzomib, lenalidomide, and dexamethasone induction and consolidation with tandem transplant in high-risk newly diagnosed myeloma patients: Final results of the phase 2 study IFM 2018-04

Cyrille Touzeau

208

Iberdomide maintenance after autologous stem-cell transplantation in newly diagnosed MM: First results of the phase 2 EMN26 study

Niels W.C.J. van de Donk

209

GEM2017FIT trial: Induction therapy with bortezomib-melphalan and prednisone (VMP) followed by lenalidomide and dexamethasone (Rd) versus carfilzomib, lenalidomide and dexamethasone (KRd) Plus/minus daratumumab (D), 18 cycles, followed by consolidation and maintenance therapy with lenalidomide and daratumumab: Phase III, multicenter, randomized trial for elderly fit newly diagnosed multiple myeloma (NDMM) Patients aged between 65 and 80 years

Maria-Victoria Mateos

339

Minimally invasive assessment of measurable residual disease (MRD) in multiple myeloma (MM)

Carmen Gonzalez

340

Mass spectrometry-based assessment of M-Protein in peripheral blood during maintenance therapy in multiple myeloma (MM) in the phase III ATLAS trial

Tadeusz Kubicki

342

Dynamic frailty status enables better prediction of survival probability - results of the HOVON 143 study

Febe Smits

533

Longitudinal screening of mutant hematopoietic progenitor cells (HPC) in multiple myeloma (MM) and its association with secondary primary malignancies (SPM)

Cristina Perez

647

Comparison of response and survival outcomes in standard- and high-risk newly diagnosed transplant-eligible multiple myeloma (NDMM) patients treated with lenalidomide, bortezomib and dexamethasone (RVD) versus daratumumab, lenalidomide, bortezomib and dexamethasone (D-RVD)

Nisha S. Joseph

1022

Updated results of a phase I open-label single-arm study of dual targeting BCMA and CD19 fastcar-T cells (GC012F) as first-line therapy for transplant-eligible newly diagnosed high-risk multiple myeloma

Juan Du

4762

Treatment outcomes and prognostic factors with lenalidomide, bortezomib, and dexamethasone (RVd) alone versus rvd plus autologous stem cell transplantation (ASCT) in African American (AA) patients (Pts) with newly diagnosed multiple myeloma (NDMM) in the determination phase 3 trial

Jeffrey A. Zonder

LBA-1

Phase 3 randomized study of daratumumab (DARA) + bortezomib, lenalidomide, and dexamethasone (VRd) versus Vrd alone in patients (Pts) with Newly diagnosed multiple myeloma (NDMM) Who are eligible for autologous stem cell transplantation (ASCT): Primary results of the Perseus trial

Pieter Sonneveld

Relapsed and/or refractory multiple myeloma

91

Real-world safety and efficacy of teclistamab for patients with heavily pretreated relapsed-refractory multiple myeloma

Danai Dima

219

BMS-986393 (CC-95266), a G protein–coupled receptor class C group 5 member D (GPRC5D)–targeted chimeric antigen receptor (CAR) T-cell therapy for relapsed/refractory multiple myeloma (RRMM): Updated results from a phase 1 study

Susan Bal

338

Venetoclax in combination with daratumumab and dexamethasone elicits deep, durable responses in patients with t(11;14) relapsed/refractory multiple myeloma: Updated analyses of minimal residual disease negativity in phase 1/2 study

Nizar J. Bahlis

761

Efficacy outcomes and characteristics of patients with multiple myeloma (MM) Who achieved sustained minimal residual disease negativity after treatment with equecabtagene autoleucel (Eque-cel, CT103A) in Fumanba-1

Chunrui Li

783

Ixazomib-based consolidation and maintenance prolongs progression-free survival after salvage autologous stem cell transplantation (sASCT): Results from interim analysis of UK-MRA Myeloma XII (ACCoRD)

Gordon Cook

1009

Randomized phase 3 study of pomalidomide cyclophosphamide dexamethasone (PCD) Versus pomalidomide dexamethasone (PD) in relapse or refractory myeloma: An Asian Myeloma Network (AMN) study

Wee-Joo Chng

1010

Efficacy and safety of less frequent/lower intensity dosing of talquetamab in patients with relapsed/refractory multiple myeloma: Results from the phase 1/2 MonumenTAL-1 study

Ajai Chari

1011

Sonrotoclax (BGB-11417) in Combination with Dexamethasone for the Treatment of Relapsed/Refractory Multiple Myeloma with t(11;14): Safety, Efficacy, and Determination of Recommended Phase 2 Dose

Hang Quach

1013

Mezigdomide (MEZI) plus dexamethasone (DEX) and daratumumab (DARA) or elotuzumab (ELO) in patients (pts) with relapsed/refractory multiple myeloma (RRMM): Results from the CC-92480-MM-002 trial

Paul G. Richardson

1014

Talquetamab + pomalidomide in patients with relapsed/refractory multiple myeloma: Safety and preliminary efficacy results from the phase 1b MonumenTAL-2 study

Jeffrey V. Matous

1021

The phase 2 CARTITUDE-2 trial: Updated efficacy and safety of ciltacabtagene autoleucel in patients with multiple myeloma and 1-3 prior lines of therapy (cohort A) and with early relapse after first line treatment (cohort B)

Jens Hilengrass

1027

Real world outcomes with idecabtagene vicleucel (Ide-Cel) CAR-T cell therapy for relapsed/refractory multiple myeloma

Surbhi Sidana

1028

Idecabtagene vicleucel (ide-cel) versus standard (std) regimens in patients (pts) with triple-class exposed (TCE) relapsed and refractory multiple myeloma (RRMM): Updated analysis from KarMMa-3

Paula Rodríguez Otero

3377

Updated results of talquetamab, a GPRC5D×CD3 bispecific antibody, in patients with relapsed/refractory multiple myeloma with prior exposure to t-cell redirecting therapies: Results of the phase 1/2 MonumenTAL-1 study

Andrzej J. Jakubowiak

3499

Alternative Lymphodepletion strategies lead to similar response rates and toxicities in standard-of-care BCMA-directed CAR-T therapy in relapsed refractory multiple myeloma

Shonali Midha

Other plasma cell dyscrasias

Top abstracts by region

In addition to the top abstracts selected by our steering committee, the Multiple Myeloma Hub would like to highlight some key region-specific abstracts in the field of multiple myeloma and plasma cell dyscrasias.

Latin America

Asia Pacific

Europe, the Middle East and Africa

ASH 2023 abstracts

To download this document, click below.

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