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The MM-003 clinical trial compared the use of pomalidomide plus either low- or high- dose dexamethasone, for the treatment of patients with relapsed and refractory (RR) Multiple Myeloma (MM), after failed treatment with bortezomib and lenalidomide. A favorable outcome was observed for pomalidomide plus low-dose dexamethasone. In an updated analysis, long-term survival was assessed along with a cytogenetic sub-group analysis, and was published in Haematologica in July 2015, by Meletios A. Dimopoulos from the National and Kapodistrian University of Athens, School of Medicine, Greece, and colleagues. Study design and treatment regimen are detailed in a previous MMHub article.
Patients (pts) were randomly assigned into pomalidomide plus low-dose dexamethasone (POM+LoDEX) or pomalidomide plus high-dose dexamethasone (POM+HiDEX)
Data are given as: POM+LoDEX vs POM+HiDEX:
This updated analysis further confirms the benefit of pomalidomide plus low-dose dexamethasone for RRMM patients across all subgroups, including those with high-risk genetic subtypes. Particular benefit of POM+LoDEX was observed for patients with del(17p), for whom outcomes were comparable to standard-risk patients. Therefore, this further supports the use of pomalidomide plus low-dose dexamethasone as a viable treatment pathway for RRMM patients, following the exhaustion of bortezomib and lenalidomide regimens.
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