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Conditioning regimens are regularly used to improve the efficacy of autologous hematopoietic stem cell transplantation (auto-HSCT) in patients with newly diagnosed multiple myeloma. However, currently, there is a lack of data surrounding the use of bortezomib (Vel) + melphalan 200 mg/m2 (Mel200) (Vel-Mel) conditioning in the upfront clinical setting.
Recently, Beksac et al.1 published a retrospective analysis in Bone Marrow Transplant investigating the outcomes of patients with newly diagnosed multiple myeloma, transplanted with Vel-Mel or Mel200. We summarize the key points below.
Figure 1. CR/VGPR rates in patients treated with Vel-Mel and Mel200 at first transplant and Day 100 posttransplant*
CR, complete response; Mel200, melphalan 200 mg/m2; Vel-Mel, bortezomib + melphalan 200 mg/m2; VGPR, very good partial response.
*Adapted from Beksac, et al.1
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