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An expert panel hosted by
Sequencing immune-based therapies in B-cell malignancies
with Ulric Jäger, Sagar Lonial, and Krina Patel
Saturday, June 15 | 18:00-19:30 CEST
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Patients with newly diagnosed multiple myeloma (NDMM) who experience an incomplete response to autologous stem cell transplantation (ASCT) have poorer outcomes, with an increased risk of progression (38%) and an increased risk of death (41%) compared with patients who experience a complete response.1 KarMMa-9 (NCT06045806) is an ongoing phase III trial comparing the efficacy and safety of idecabtagene vicleucel (ide-cel) plus lenalidomide for maintenance vs lenalidomide alone in patients with NDMM who had a suboptimal response (partial response or very good partial response) to ASCT.
Here we summarize a poster presentation by Mateos, et al.1 from the 5th European Myeloma Network Meeting, 2024, on the rationale and study design of the phase III KarMMa-9 trial.1
Figure 1. KarMMa-9 study design*
CAR, chimeric antigen receptor; ide-cel, idecabtagene vicleucel; LDC, lymphodepleting chemotherapy; OS, overall survival; PD, progressive disease; PFS, progression-free survival.
*Adapted from Mateos, et al.1
†Apheresis to be performed within 14−42 days after last dose of R.
‡Fludarabine 30 mg/m2 and cyclophosphamide 300 mg/m2 on Days -5, -4, and -3 prior to ide-cel infusion.
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