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During the 65th American Society of Hematology (ASH) Annual Meeting and Exposition, the Multiple Myeloma Hub spoke to Shaji Kumar, Mayo Clinic, Rochester, US. We asked, How do response rates observed in clinical trials translate into real-world outcomes in multiple myeloma?
How do response rates observed in clinical trials translate into real-world outcomes in MM?
Kumar discusses the characteristics of patients in clinical trials versus those treated in the real-world setting, highlighting the stringent inclusion/exclusion criteria and their impact on the generalizability of clinical trial results. He then explores how risk status, drug toxicity, and tolerability impact the real-world effectiveness of treatment. Kumar concludes by highlighting the differences between initial response rates seen in clinical trials and how this translates into longer-term outcomes, such as durability of response and progression-free survival.
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