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Clinical imaging is increasingly used for both diagnosis and therapeutic assessment of numerous cancers. Fluorine-18 fluorodeoxyglucose positron emission tomography (PET) with computed tomography (CT) attenuation correction (18F-FDG PET/CT) evaluates glucose metabolism, providing a quantitative readout for the presence of active lesions.
Faith E. Davies, from the Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR, US, and colleagues, conducted a study in which they analyzed the prognostic significance of suppressing PET/CT activity in focal lesions (FLs) of newly diagnosed multiple myeloma (NDMM) patients, at various time points after therapeutic intervention. The study was published in Haematologica in March 2018.
This analysis demonstrates the valuable contribution of PET-CT imaging to the prediction of clinical outcome. NDMM patients who displayed no PET-CT FL activity after treatment by day 7, or by the end of induction, displayed a similar clinical outcome to patients who presented with no FLs at the time of diagnosis. Additionally, the results demonstrate a strong association between NDMM patients with 3 or more focal lesions and a poor PFS and OS. The authors of this study propose the integration of serial PET-CT as part of a strategic treatment plan.
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