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2021-10-29T09:26:27.000Z

The safety and efficacy of a reduced toxicity regimen in frail patients with NDMM

Oct 29, 2021
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How do you adapt MM treatment regimens for frail patients?

Same until AE

22%

Reduced dose

55%

Shorter treatment

11%

Skip doses

11%

9 votes

Frail patients diagnosed with multiple myeloma (MM) are not transplant eligible; thus, the recommended frontline treatment consists of a combination of the anti-CD38 antibody, daratumumab, with either lenalidomide and low-dose dexamethasone, or low-dose bortezomib-based combinations. Such regimens appear to be safe and effective for newly diagnosed MM, however, clinical trials have historically included patients of various baseline performance statuses. Therefore, it has been difficult to gauge the precise safety and tolerability in the frail population, which has been reported to achieve shorter survival and higher discontinuation rates.1

Stege et al. recently performed a prospective study; HOVON-143, which explored the efficacy and safety data on a reduced toxicity regimen; ixazomib-daratumumab-low-dose-dexamethasone (Ixa-Dara-dex). This study has been long awaited for being the first to include only frail patients characterized by age or comorbidities. Find below further details on the recently published analysis in the Journal of Clinical Oncology.1 We have previously provided a summary of this and other studies with similar approaches in elderly patients.

Study design

This was a prospective, multicenter phase II trial conducted at 39 hospitals throughout the Netherlands and Belgium. The study design is summarized in Figure 1.

Figure 1. HOVON-143 study design*

IV, intravenous.
*Adapted from Stege et al.1
Each induction cycle (Cycles 19) lasted 28 days.
Maintenance was performed until progression for a maximum of 2 years.

Eligibility criteria

  • Previously untreated symptomatic MM
  • Frail patients, according to the IMWG-frailty index
  • Absolute neutrophil count 1.0 × 109/L; platelet count ≥75 x 109/L
  • Must not have severe organ dysfunction (New York Heart Association Class III and IV)
  • Creatinine clearance ≥20 mL/min
  • Patients with neuropathy Grade ≥1 with pain or Grade ≥2 and active or uncontrolled infections were excluded

Results

Patient characteristics are summarized in Table 1.

Table 1. Patient characteristics*

Characteristic

N = 65

Median age, years (range)

81 (70–92)

Frailty status, %

 

              Based on age alone

20

              Based on other parameters

49

              Based on both age and other frailty parameters

31

IMWG frailty score, %

 

              2

49

              3

29

              4

20

              5

2

R-ISS disease stage, %

 

              I

15

              II

38

              III

18

              Unknown

18

Median creatinine clearance (mL/min, range)

56 (2090)

IMWG, International Myeloma Working Group; R-ISS, Revised International Staging System.
*Adapted from Stege et al.1
IMWG score for frail status is ≥2

Efficacy

The overall response rate was 78% (95% confidence interval, 0.73–0.82), 8% of whom had a stringent complete response, 28% who had a very good partial response, and 43% who had a partial response. The median time to first response was 1 month (range, 1–6 months) and the median duration of response was 11 months (range, 1–26 months). Survival outcomes after a median follow-up of 22.9 months are summarized in Table 2.

Table 2. Survival outcomes after a median follow-up of 22.9 months*

Outcome

N = 65

95% CI

Median PFS, months

13.8

 

              Frail based on age alone

21.6

9.2–not reached

     Frail based on other parameters

13.8

7.8–not reached

     Both age >80 years and other parameters

10.1

3.3–21.4

Mortality, %

38

12-month OS, %

78

66–87

     Frail based on age alone

92

57–99

     Frail based on other parameters

78

59–89

     Both age >80 years and other parameters

70

44–85

CI, confidence interval; OS, overall survival; PFS, progression-free survival.
*Adapted from Stege et al.1

A total of 13 patients died while on the treatment protocol, of which three cases were attributed to disease progression. For the other ten patients, causes of non-relapse mortality included infection (40%), organ dysfunction (30%), sudden death (20%), and bleeding because of thrombocytopenia (10%).

Safety

A total of 33 (65%) patients discontinued treatment during induction, with the most common reasons summarized in Table 3.

Table 3. Reasons for discontinuing the ixazomib-daratumumab-low-dose-dexamethasone regimen*

Reason for discontinuation, %

N = 65

Progression

19

Intercurrent death

9

Toxicity

9

Noncompliance to treatment

6

Other reasons

8

Infection

6

*Adapted from Stege et al.1

The discontinuation rate was greater in patients aged >80 years with or without frail comorbidities compared with younger patients (30% and 38% vs 13%, respectively).

A total of 32 (49%) patients started maintenance therapy, of whom 47% discontinued after a median follow-up of 13.6 months, mainly because of disease progression.

The incidence of hematologic and non-hematologic Grade ≥3 adverse events and serious adverse events were comparable between the three frail subgroups. The most common events after a median follow-up of 22.9 months are summarized in Table 4.

Table 4. Incidence of Grade ≥3 or serious AEs*

AE, %

N = 65

Grade ≥3 hematologic

31

              Anemia

3

              Thrombocytopenia

23

              Neutropenia

9

Grade ≥3 non-hematologic

74

              Infections

25

              GI

13

              Cardiac

11

              Peripheral neuropathy

6

Serious AEs

81.5

AE, adverse event; GI, gastrointestinal.
*Adapted from Stege et al.1

Finally, all patients completed a health-related quality of life questionnaire at baseline, after three induction cycles (96.6% compliance), and after nine cycles (92.7% compliance). The investigators observed a statistically significant improvement in global health score or quality of life score from baseline to after three cycles, which further improved by cycle nine (54.1, 65.8, and 71.5, respectively; p < 0.001).

Conclusion

Overall, this study demonstrated that a non-toxic regimen could produce effective responses in frail patients. However, patients on this protocol experienced a high rate of Grade ≥3 and serious adverse events, and as such, a relatively high early mortality rate, discontinuation rate, and reduced long-term compliance. Such observations were found both in frail patients characterized by age and by comorbidities. Besides the need to explore alternative regimens with reduced toxicity in this vulnerable population, more trials are necessary with a larger sample size to allow for multivariate analyses and to accurately identify prognostic factors associated with adverse clinical outcomes.  

  1. Stege CAM, Nasserinejad K, van der Spek E, et al. Ixazomib, daratumumab, and low-dose dexamethasone in frail patients with newly diagnosed multiple myeloma: The Hovon 143 study. J Clin Oncology. 2021;39(25):2758-2767. DOI: 1200/JCO.20.03143

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