All content on this site is intended for healthcare professionals only. By acknowledging this message and accessing the information on this website you are confirming that you are a Healthcare Professional. If you are a patient or carer, please visit the International Myeloma Foundation or HealthTree for Multiple Myeloma.
The Multiple Myeloma Hub uses cookies on this website. They help us give you the best online experience. By continuing to use our website without changing your cookie settings, you agree to our use of cookies in accordance with our updated Cookie Policy
Introducing
Now you can personalise
your Multiple Myeloma Hub experience!
Bookmark content to read later
Select your specific areas of interest
View content recommended for you
Find out moreThe Multiple Myeloma Hub website uses a third-party service provided by Google that dynamically translates web content. Translations are machine generated, so may not be an exact or complete translation, and the Multiple Myeloma Hub cannot guarantee the accuracy of translated content. The Multiple Myeloma Hub and its employees will not be liable for any direct, indirect, or consequential damages (even if foreseeable) resulting from use of the Google Translate feature. For further support with Google Translate, visit Google Translate Help.
The Multiple Myeloma Hub is an independent medical education platform, sponsored by Bristol Myers Squibb, GSK, Johnson & Johnson, Pfizer, Roche and Sanofi. The levels of sponsorship listed are reflective of the amount of funding given. Digital educational resources delivered on the Multiple Myeloma Hub are supported by an educational grant from Janssen Biotech, Inc. View funders.
Ixazomib in combination with daratumumab and dexamethasone for the treatment of RRMM
Bookmark this article
|
Ixazomib, an oral proteasome inhibitor, is approved in combination with lenalidomide and dexamethasone for the treatment of MM after ≥1 prior therapy. However, lenalidomide is also commonly used in the first-line and lenalidomide-refractory disease is frequent, highlighting the need for lenalidomide-free alternatives in the relapsed/refractory setting. Data from a phase II study (NCT03439293) evaluating ixazomib in combination with daratumumab and dexamethasone (IDd) in RRMM, including those with hard-to-treat and lenalidomide-refractory disease, were presented in the American Journal of Hematology by Delimpasi et al.1
|
| Key learnings: |
|
At the final analysis of this phase II trial, ORR was 64.4%, with a ≥VGPR of 30.5% in response-evaluable patients treated with IDd (n = 59). |
|
Response rates among the subgroups analyzed were 53.3% in patients with high-risk cytogenetics, 58.3% in patients with expanded high-risk cytogenetics, 50.0% in patients aged ≥75 years, and 61.9% in lenalidomide-refractory patients. |
|
The median PFS for patients treated with IDd was 16.8 months. Median PFS was comparable in those with high-risk cytogenetics (8.7 months) and in those refractory to lenalidomide (12.6 months). |
|
54.1% of patients experienced Grade ≥3 TEAEs, with 1.6% of patients having Grade ≥3 peripheral neuropathy. |
|
TEAEs led to dose modifications, reductions, and discontinuations in 62.3%, 36.1%, and 16.4% of patients, respectively. |
|
Data presented highlight the IDd regimen as a tolerable treatment option for patients with RRMM, including for those with high-risk features. As an all-oral, lenalidomide-free option, it provides an alternative for potentially difficult to treat patients. |
Abbreviations: IDd, ixazomib-daratumumab-dexamethasone; MM, multiple myeloma; ORR, overall response rate; PFS, progression-free survival; RRMM, relapsed/refractory multiple myeloma; TEAE, treatment-emergent adverse events; VGPR, very good partial response.
- Delimpasi S, Dimopoulos M, Straub J, et al. Ixazomib plus daratumumab and dexamethasone: Final analysis of a phase 2 study among patients with relapsed/refractory multiple myeloma. Am J Hematol. 2024;99(9):1746-1756. DOI: 10.1002/ajh.27382
Your opinion matters
2 votes - 43 days left ...
Related articles
Newsletter
Subscribe to get the best content related to multiple myeloma delivered to your inbox