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During the 63rd ASH Annual Meeting and Exposition, the Multiple Myeloma Hub was pleased to speak to Luciano J. Costa, University of Alabama at Birmingham, Birmingham, US. We asked, Is there still a role in multiple myeloma for autologous stem cell transplant (auto-SCT) after induction with a quadruplet combination?
Is there still a role in MM for auto-SCT after induction with a quadruplet combination?
In this video, Costa discusses the MASTER trial (NCT03224507), which involves the quadruplet drug combination of daratumumab, carfilzomib, lenalidomide, and dexamethasone (KRdD), followed by auto-SCT. The MASTER trial, updated during this congress, is critical to understand further how to implement minimal residual disease (MRD)-guided treatment decisions in the frontline setting and refine the use of auto-SCT.
MASTER trial | Monoclonal antibody-based quadruplet regimen (Dara-KRd) with MRD–based response-adapted therapy in patients with NDMM
Summary of Abstract #860 presented at ASH | Monoclonal antibody-based quadruplet regimen (daratumumab-KRd) with...
Can MRD guide treatment of post-transplant dara-KRd consolidation?
Luciano J. Costa, University of Alabama at Birmingham, Birmingham, US, answers the question: Can the minimal residual disease (MRD) status guide combination treatment of daratumumab...
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