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Initial results from the phase II MagnetisMM-6 study: Part 1, dose level G

By Jennifer Reilly

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Oct 6, 2025

Learning objective: After reading this article, learners will be able to recall the latest data from the MagnetisMM-6 trial of elranatamab with DR for TI-NDMM


Do you know... Part 1 of the MagnetisMM-6 trial has confirmed the phase III dosing regimen of elranatamab to be evaluated in combination with daratumumab and lenalidomide in part 2 of the study. What is it?

During the European Hematology Association (EHA) 2025 Congress, June 12–15, 2025, Milan, IT, Meletios A. Dimopoulos shared the initial results from the phase II MagnetisMM-6 study (NCT05623020) part 1, dose level G of elranatamab in combination with daratumumab and lenalidomide (EDR) for the treatment of transplant-ineligible newly diagnosed multiple myeloma.  

Dose level G consisted of EDR administered in 28-day cycles, with subcutaneous elranatamab 76 mg every 4 weeks. The dose level G informed the recommended phase III dose of elranatamab for part 2 of MagnetisMM-6, due to its benefit–risk balance. 

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