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B-cell maturation antigen (BCMA)-directed immunotherapies for the treatment of relapsed/refractory multiple myeloma (RRMM) are often associated with high response rates compared with standard of care treatments. However, they are often also accompanied by cytokine elevation, which can lead to cytokine release syndrome (CRS). The incidence of CRS associated with BCMA-directed therapies is well established but rarely stratified by modality and administration route.1
Here, we summarize a meta-analysis by Soltantabar et al.1 published in Clinical Pharmacology and Therapeutics on the impact of treatment modality and the route of administration of immunotherapies on the incidence of CRS in RRMM.
Figure 1. CRS rates associated with CAR T-cell and bispecific antibody therapies*
bsAbs, bispecific antibody; CAR, chimeric antigen receptor.
*Data from Soltantabar, et al.1
Table 1. Incidence of CRS by agent and dose level*
Drug |
Dose level |
Any grade CRS, % |
Grade ≥3 CRS, % |
---|---|---|---|
Elranatamab |
12/32/76 mg |
56.3 |
0 |
4/20/76 mg |
64.4 |
0 |
|
44/76 mg; no premed |
100 |
0 |
|
44/76 mg premed |
78.3 |
4.3 |
|
1,000 μg/kg (76 mg) |
100 |
0 |
|
600 μg/kg (44 mg) |
100 |
0 |
|
Linvoseltamab |
5/20/50 mg IV |
54.8 |
1.9 |
5/20/200 mg IV |
45.3 |
0.8 |
|
Alnuctamab |
3/6/10 mg SC |
72 |
0 |
3/6/30 mg SC |
44 |
0 |
|
3/6/10 mg IV |
71 |
2 |
|
ABBV-383 |
40 mg IV |
69 |
0 |
60 mg IV |
70 |
2 |
|
CRS, cytokine release syndrome; IV, intravenous; SC, subcutaneous. |
Key learnings1 |
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