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What are the management strategies for CRS and ICANS in MM?

By Jennifer Reilly

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Hermann EinseleHermann Einsele

Mar 1, 2024

Learning objective: After reading this article, learners will be able to cite a new clinical development in relapsed/refractory MM


During the 65th American Society of Hematology (ASH) Annual Meeting and Exposition, the Multiple Myeloma Hub spoke to Hermann Einsele, Julius-Maximilians-Universität Würzburg, Würzburg, DE. We asked, What are the management strategies for cytokine release syndrome and immune effector cell-associated neurotoxicity in multiple myeloma?

What are the management strategies for CRS and ICANS in MM?

Einsele discusses the management of cytokine release syndrome and immune effector cell-associated neurotoxicity in patients treated with common immunotherapies such as chimeric antigen receptor T cells and bispecific antibodies. He then outlines the incidence and risk factors associated with immune-mediated toxicities from these immunotherapies. Finally, Einsele concludes by exploring several therapeutic strategies, including the use of bridging therapies, prophylactic steroids, and supportive care.

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