TRANSLATE

The mm Hub website uses a third-party service provided by Google that dynamically translates web content. Translations are machine generated, so may not be an exact or complete translation, and the mm Hub cannot guarantee the accuracy of translated content. The mm and its employees will not be liable for any direct, indirect, or consequential damages (even if foreseeable) resulting from use of the Google Translate feature. For further support with Google Translate, visit Google Translate Help.

The Multiple Myeloma Hub is an independent medical education platform, sponsored by Bristol Myers Squibb, GSK, Johnson & Johnson, Pfizer, Roche and Sanofi. The levels of sponsorship listed are reflective of the amount of funding given. View funders.

Now you can support HCPs in making informed decisions for their patients

Your contribution helps us continuously deliver expertly curated content to HCPs worldwide. You will also have the opportunity to make a content suggestion for consideration and receive updates on the impact contributions are making to our content.

Find out more

How is CT053 different from other BCMA-directed CAR T-cell therapies?

Featured:

Shaji KumarShaji Kumar

Dec 17, 2020


Video series

During the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition, the Multiple Myeloma Hub spoke to Shaji K. Kumar, Mayo Clinic, Rochester, US. We asked, How is CT053 different from other B-cell maturation antigen (BCMA)-directed chimeric antigen receptor (CAR) T-cell therapies?

CT053 consists of autologous T cells genetically modified with a CAR incorporating a fully human BCMA-specific single-chain fragment variant, a 4-1BB intracellular domain, and a CD3 intracellular signaling region. The advantage over other CAR T-cell therapies is that it has a shorter manufacturing time, of 8–10 days, which allows a shorter interval between apheresis and infusion. Kumar reports the results of an ongoing phase I/II trial evaluating the safety and efficacy of CT053 in patients with relapsed/refractory multiple myeloma.