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Sequencing immune-based therapies in B-cell malignancies
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Immune-based therapies in multiple myeloma (MM) include agents such as chimeric antigen receptor (CAR) T cells, as well as bispecific antibody therapies. These novel agents are often associated with high initial response rates compared with standard therapies, yet most patients go on to experience a relapse. In an effort to improve duration of response, dual antigen targeting and trispecific antibodies are currently being investigated in MM.1
Here we summarize a presentation by Sham Mailankody1 from the International Myeloma Society’s 5th Immune Effector Cell Therapies in Multiple Myeloma Workshop, 2024, on antigen-targeting CAR T cells and antibody therapies in MM.
Figure 1. Methods of dual antigen-targeting in MM*
CAR, chimeric antigen receptor; TCE, T-cell engager.
Created with BioRender.com.
*Adapted from Mailankody.1
Figure 2. Response rates from RedirecTT-1 in A response-evaluable patients and B patients with EMD*
CR, complete response; PR, partial response; Q2W, once every 2 weeks; sCR, stringent complete response; tal, talquetamab; tec, teclistamab; VGPR, very good partial response.
*Adapted from Mailankody.1
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