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Ben DermanDuring the 64th American Society of Hematology (ASH) Annual Meeting and Exposition, the Multiple Myeloma Hub was pleased to speak to Benjamin Derman, University of Chicago, Chicago, US. We asked, What are the main improvements in next-generation chimeric antigen receptor (CAR) T-cell products?
What are the main improvements in next-generation CAR T-cell products?
In this video, Derman considers multiple abstracts1–3 presented at ASH 2022 on studies that aim to improve CAR T-cell products, including the development of CAR T-cell therapies that can interact simultaneously with multiple targets, such as BCMA and CD19. Derman also discusses the possibility of reducing turnaround times by optimizing the manufacturing process, as well as developing CAR T‑cell products that can interact with new targets such as GPRC5D. Improvements in the persistence and immune tolerance of CAR T-cell therapies and initiating therapy in earlier lines are also considered.
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