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What are the main improvements in next-generation CAR T-cell products?

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Jan 3, 2023
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Learning objective: After reading this article, learners will be able to cite a new clinical development in relapsed/refractory MM

During the 64th American Society of Hematology (ASH) Annual Meeting and Exposition, the Multiple Myeloma Hub was pleased to speak to Benjamin Derman, University of Chicago, Chicago, US. We asked, What are the main improvements in next-generation chimeric antigen receptor (CAR) T-cell products?

What are the main improvements in next-generation CAR T-cell products?

In this video, Derman considers multiple abstracts13 presented at ASH 2022 on studies that aim to improve CAR T-cell products, including the development of CAR T-cell therapies that can interact simultaneously with multiple targets, such as BCMA and CD19. Derman also discusses the possibility of reducing turnaround times by optimizing the manufacturing process, as well as developing CAR T‑cell products that can interact with new targets such as GPRC5D. Improvements in the persistence and immune tolerance of CAR T-cell therapies and initiating therapy in earlier lines are also considered.

  1. Du J, Fu W, Lu J, et al. Phase I open-label single-arm study of BCMA/CD19 dual-targeting FasTCAR-T cells (GC012F) as first-line therapy for transplant-eligible newly diagnosed high-risk multiple myeloma. Oral abstract #366. Presented at: 64th American Society of Hematology Annual Meeting and Exposition; Dec 10, 2022; New Orleans, US.
  2. Bal S, Kocoglu MH, Nadeem O, et al. Clinical activity of BMS-986393 (CC-95266), a G protein–coupled receptor class C Group 5 member D (GPRC5D)–targeted chimeric antigen receptor (CAR) T cell therapy, in patients with relapsed and/or refractory (R/R) multiple myeloma (MM): First results from a phase 1, multicenter, open-label study. Oral abstract #364. Presented at: 64th American Society of Hematology Annual Meeting and Exposition; Dec 10, 2022; New Orleans, US.
  3. Megala Costa LJ, Kumar SK, Atrash S, et al. Results from the first phase 1 clinical study of the B-cell maturation antigen (BCMA) NEX T chimeric antigen receptor (CAR) T cell therapy CC-98633/BMS-986354 in patients (pts) with relapsed/refractory multiple myeloma (RRMM). Oral abstract #566. Presented at: 64th American Society of Hematology Annual Meeting and Exposition; Dec 11, 2022; New Orleans, US.