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It has been announced today, 12 February, 2019, that the National Institute for Health and Care Excellence (NICE), will make the triplet regimen; daratumumab (Darzalex®), bortezomib (Velcade®) and dexamethasone (DVd), available to patients with multiple myeloma (MM) in England through the Cancer Drugs Fund (CDF). Patients will be eligible to receive DVd if they have already received one prior line of therapy. The triplet regimen will not, however, be routinely available until the long-term survival benefit can be supported by further data and re-evaluated by NICE.1
Daratumumab is an anti-CD38 monoclonal antibody, bortezomib is a proteasome inhibitor and dexamethasone is a corticosteroid. This triplet combination was compared to bortezomib-dexamethasone (Vd) alone in the phase III CASTOR trial (NCT02136134).2
Data given as DVd versus Vd
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