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Masterclass | BCMA-CD3 bispecific antibodies in MM: Current and evolving roles

By Jennifer Reilly

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Sagar LonialSagar LonialHang QuachHang QuachAlexander Lesokhin

Sep 15, 2025

Learning objective: After reading this article, learners will be able to cite a new clinical development in multiple myeloma.


The clinical development of B-cell maturation antigen (BCMA)-CD3 directed bispecific antibody therapies represents an important advancement in the treatment of multiple myeloma (MM), with their role in clinical practice continuing to evolve.

The Multiple Myeloma Hub spoke with Hang Quach, Alexander Lesokhin, and Sagar Lonial to gain their expert perspectives on how these agents are being used in real-world practice, combination strategies under investigation, and future applications for BCMA-directed bispecifics in the treatment of MM and other plasma cell dyscrasias.

This educational resource is independently supported by Pfizer. All content was developed by SES in collaboration with an expert steering committee. Funders were allowed no influence on the content of this resource.

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