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Multiple myeloma (MM) often progresses from an asymptomatic phase, called smoldering multiple myeloma (SMM). The risk of progression is 10% per year, however the presence of adverse prognostic factors can lead this to increase to 25%. The current standard of care for SMM is observation. Early interventions, from a preventative approach with low-intensity therapy, through to a more intensive approach, might prevent end-organ damage.
In this paper, Sagar Lonial, Emory University, Atlanta, GA, and colleagues hypothesized that early interventions could delay progression to MM. They conducted a randomized trial wherein patients with intermediate- or high-risk SMM received either lenalidomide or observation. The results of this trial were previously presented by Sagar Lonial at the American Society of Clinical Oncology (ASCO) meeting earlier this year and covered by the MM Hub.
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