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How do MM cells develop resistance to BCMA-targeted agents? Can it be overcome in the clinic?

During the EHA2021 Virtual Congress, the Multiple Myeloma Hub spoke with Leo Rasche, University Hospital of Würzburg, Würzburg, DE. We asked, How do multiple myeloma cells develop resistance to B-cell maturation antigen (BCMA)-targeted agents? Can it be overcome in the clinic?

In this video,  Rasche discusses the recent discovery of a resistance mechanism to anti-BCMA therapies, which include both bispecific antibodies and chimeric antigen receptor T-cell therapies.

For more information about BCMA-resistance mechanisms, read our latest review here.