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FDA clears investigational new drug application for ALLO-605 for multiple myeloma

Apr 21, 2021
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On April 19, 2021, it was announced that the U.S. Food and Drug Administration (FDA) cleared an investigational new drug (IND) application for ALLO-605 for the treatment of relapsed/refractory multiple myeloma.1 ALLO-605 is an allogeneic chimeric antigen receptor (CAR) T-cell therapy targeting the B-cell maturation antigen (BCMA).

Besides their anti-BCMA effect, ALLO-605 cells co-express a constitutively active chimeric cytokine receptor or turbodomain, which provides CAR T-cell intrinsic cytokine signaling. Preclinical studies found that the ALLO-605 design could recapitulate cytokine signaling to control T cell exhaustion, reduce rejection, and improve T cell function and potency to reduce the dose of T cells needed.1,2

This IND clearance allows for the commencement of the phase I IGNITE trial, due to start later this year, which will evaluate escalating doses of ALLO-605.1

For more information on anti-BCMA allogeneic CAR T cells, read our article here.

  1. Allogene Therapeutics. Allogene Therapeutics Receives IND Clearance from the U.S. Food and Drug Administration for ALLO-605, the First TurboCAR™ Candidate, for the Treatment of Patients with Relapsed/Refractory Multiple Myeloma. https://ir.allogene.com/news-releases/news-release-details/allogene-therapeutics-receives-ind-clearance-us-food-and-drug-0. Published Apr 19, 2021. Accessed Apr 20, 2021.
  2. Allogene Therapeutics. TurboCAR™: Turbocharging CAR T cells. https://www.allogene.com/allocar-t-therapy#turboCars. Accessed Apr 20, 2021.

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