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On November 30, 2021, it was announced that the U.S. Food and Drug Administration (FDA) approved the use of subcutaneous daratumumab (daratumumab + hyaluronidase-fihj) in combination with carfilzomib and dexamethasone (Dara-Kd) for the treatment of adult patients with relapsed/refractory multiple myeloma (R/R MM) with ≤3 prior lines of therapy. The decision was based on results of a single cohort of patients in the ongoing PLEIADES trial (NCT03412565).1
Subcutaneous daratumumab (1,800 mg/30,000 units daratumumab/hyaluronidase) and dexamethasone are administered as per standard dosing.
The recommended dosing of carfilzomib intravenously over 30 minutes in each 28-day cycle is:
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