EMN recommendations for the management of MM and COVID-19 in the post-pandemic era

COVID-19 infections present an increased risk to patients with multiple myeloma (MM); characterized by higher rates of hospitalization and death.¹ In the post-pandemic era, the management of patients with MM is generally improved, resulting in fewer cases of severe COVID‑19. However certain anti-myeloma therapies such as anti-CD38 antibodies and BCMA targeted therapies increase the risk of severe COVID-19.¹

The European Myeloma Network (EMN) has provided recommendations for the management of patients with MM to reduce the incidence of infection-related poor outcomes in COVID-19.¹ The Multiple Myeloma Hub is pleased to summarize this consensus here.

Vaccination for COVID-19

Patients with MM are often immunodeficient, which can limit the durability of response to vaccination. The typically advanced age of patients with MM, as well as other disease-related comorbidities, further reduce the overall effectiveness of the COVID-19 vaccine. To address this, the EMN highlight booster vaccinations as key in managing these patients.

The EMN recommendations for COVID-19 vaccinations in patients with MM are highlighted in Figure 1.

auto-HSCT, autologous hematopoietic stem cell transplantation; BCMA, B-cell maturation antigen; MM, multiple myeloma.
*Data from Terpos, et al.¹

Pre-exposure prophylaxis and treatment for COVID-19

The use of pre-exposure prophylaxis interventions is beneficial to patients with MM as a preventative method to reduce the risk of severe COVID-19 requiring hospitalization. Figure 2 outlines the recommended prophylaxis strategies for COVID-19 in patients with MM.

EMA, European Medicines Agency; FDA, U.S. Food and Drug Administration; MM, multiple myeloma.
*Data from Terpos, et al.¹

Following symptom onset and a positive test result for COVID-19, swift treatment is optimal to reduce the likelihood of poor outcomes. The recommended therapies for the treatment of COVID‑19, as well as considerations for managing existing myeloma treatment, are outlined in Figure 3.

MM, multiple myeloma.
*Data from Terpos, et al.¹

Conclusion

In the post-pandemic era, patients with MM remain at a higher risk of severe COVID‑19 compared with the general population. However, emerging strains pose a lower risk than the initial strains. Prophylaxis efforts remain at the forefront of protecting patients with MM; vaccination and personal protective measures such as wearing masks are key to mitigating the risk of infection and hospitalization. Certain subsets of patients with MM remain at a higher risk, specifically those receiving anti-BCMA therapies. Antiviral therapies or remdesivir can be used to treat patients with symptomatic COVID‑19 due to their effectiveness against Omicron subvariants.