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2022-06-06T13:27:21.000Z

EHA2022 abstracts: What's hot in multiple myeloma?

By Marta Llobet-Canela, Becky Gribbell, Ella Dixon
Featured
Elena Zamagni
Heinz Ludwig
Hermann Einsele
María-Victoria Mateos
Miles Prince
Paul Richardson
Sagar Lonial
Sonja Zweegman
Jun 6, 2022
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Learning objective: After reading this article, learners will be able to cite a new clinical development in multiple myeloma.

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To help navigate the exciting content being presented at the EHA2022 Congress, the Multiple Myeloma Hub Steering Committee members have provided their recommendations for the top abstracts to look out for in multiple myeloma and other plasma cell dyscrasias.

Newly diagnosed multiple myeloma

LB2366

Phase 3 DETERMINATION trial in newly diagnosed multiple myeloma: lenalidomide, bortezomib and dexamethasone (RVD) ± autologous stem cell transplantation and lenalidomide maintenance to progression

S175

ATLAS: A phase 3 randomized trial of carfilzomib, lenalidomide, and dexamethasone versus lenalidomide alone after stem-cell transplant for multiple myeloma

S176

Daratumumab, carfilzomib, lenalidomide, and dexamethasone as induction therapy in high-risk transplant eligible newly diagnosed myeloma patients: Results of the phase 2 study IFM 2018-04

S178

Safety and efficacy of belantamab mafodotin in combination with Rd in newly diagnosed, transplant ineligible multiple myeloma patients: A phase 1/2 study by the Hellenic Society of Hematology

S179

Randomized comparison between KRd and KTd induction, followed by K maintenance or observation in transplant non-eligible patients with NDMM (AGMT-MM02 trial)

Relapsed/refractory multiple myeloma

S103

Efficacy and safety of ARI0002H, an academic BCMA-directed CAR-T cell therapy with fractionated initial therapy and booster dose in patients with relapsed/refractory multiple myeloma

S184

Evaluating teclistamab in patients with relapsed/ refractory multiple myeloma following exposure to other B-cell maturation antigen (BCMA)-targeted agents

S185

CARTITUDE-2 Cohort B: Updated clinical data and biological correlative analyses of ciltacabtagene autoleucel in patients with multiple myeloma and early relapse after initial therapy

S188

Teclistamab in combination with daratumumab, a novel, immunotherapy-based approach for the treatment of relapsed/refractory multiple myeloma: Updated phase 1b results

S263

Phase I open-label single arm study of GPRC5D CAR-T cells (ORICAR-017) In patients with relapsed/refractory multiple myeloma (POLARIS)

P1463

Phase I dose escalation of LAVA-051, a novel bispecific gamma-delta T-cell engager (GAMMABODY™), in relapsed/refractory hematological malignancies

Other

S244

Effect of anti-spike neutralizing monoclonal antibodies on COVID-19 progression and time to viral clearance in patients with hematological malignancies and SARS-COV-2 infection: The GIMEMA experience

P914

Efficacy and safety of belantamab mafodotin monotherapy in patients with relapsed or refractory light chain amyloidosis: A phase 2 study by the European Myeloma Network

EHA2022 abstracts

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More about...
AL amyloidosisBCMA CAR-TBelantamab mafodotinCAR therapyCarfilzomibCARTITUDE-2Ciltacabtagene autoleucelCOVID-19DaratumumabEHAEHA 2022High-riskLenalidomideNewly diagnosed multiple myelomaRelapsed/refractory multiple myelomaT-cell engagersTeclistamab

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