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2024-06-17T12:58:21.000Z

DREAMM-8: Belantamab mafodotin in lenalidomide-exposed patients with RRMM

Jun 17, 2024
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Learning objective: After reading this article, learners will be able to cite a new clinical development in multiple myeloma.

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Analysis of the phase III DREAMM-8 trial (NCT04484623) of belantamab mafodotin, pomalidomide, and dexamethasone (BPd) compared with pomalidomide, bortezomib, and dexamethasone (PVd), in lenalidomide-exposed patients with relapsed/refractory multiple myeloma (RRMM) by Dimopoulos et al.1 has been published in The New England Journal of Medicine this week. The primary end point was progression-free survival (PFS), and disease response and safety were also assessed. 

Key learnings:

The DREAMM-8 trial met its primary endpoint; BPd significantly improved PFS (12-month PFS of 71% vs 51% for PVd) and offers deeper, more durable responses compared with PVd in patients with RRMM who have been exposed to lenalidomide. 

The high incidence of ocular events with BPd (89%) requires careful management and dose adjustments but does not negate the substantial benefits in disease control. 

These findings suggest BPd could be a valuable therapeutic option for managing RRMM, particularly in lenalidomide-refractory cases. 

  1. Dimopoulos M, Beksac M, Pour L, et al. Belantamab mafodotin, pomalidomide, and dexamethasone in multiple myeloma. N Engl J Med. 2024. Online ahead of print. DOI: 10.1056/NEJMoa2403407. 

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