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DREAMM-8: Belantamab mafodotin in lenalidomide-exposed patients with RRMM
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Analysis of the phase III DREAMM-8 trial (NCT04484623) of belantamab mafodotin, pomalidomide, and dexamethasone (BPd) compared with pomalidomide, bortezomib, and dexamethasone (PVd), in lenalidomide-exposed patients with relapsed/refractory multiple myeloma (RRMM) by Dimopoulos et al.1 has been published in The New England Journal of Medicine this week. The primary end point was progression-free survival (PFS), and disease response and safety were also assessed.
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| Key learnings: |
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The DREAMM-8 trial met its primary endpoint; BPd significantly improved PFS (12-month PFS of 71% vs 51% for PVd) and offers deeper, more durable responses compared with PVd in patients with RRMM who have been exposed to lenalidomide. |
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The high incidence of ocular events with BPd (89%) requires careful management and dose adjustments but does not negate the substantial benefits in disease control. |
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These findings suggest BPd could be a valuable therapeutic option for managing RRMM, particularly in lenalidomide-refractory cases. |
- Dimopoulos M, Beksac M, Pour L, et al. Belantamab mafodotin, pomalidomide, and dexamethasone in multiple myeloma. N Engl J Med. 2024. Online ahead of print. DOI: 10.1056/NEJMoa2403407.
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