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CAMMA-2 Cohort A1: Cevostamab in patients with RRMM and prior BCMA-targeted ADC or CAR T-cell therapy
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CAMMA-2 (NCT05535244) is an ongoing phase I/II study evaluating the efficacy and safety of cevostamab (a FcRH5xCD3 bispecific antibody) in patients with relapsed/refractory multiple myeloma (RRMM) who are triple-class refractory and have received a prior BCMA-targeted agent. Analysis of Cohort A1 (n = 21), which enrolled patients with prior exposure to BCMA-targeted antibody–drug conjugate (ADC) or chimeric antigen receptor (CAR) T-cell therapy, was presented at EHA 2024 by Shaji Kumar. |
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In CAMMA-2, following treatment with cevostamab, the overall response rate (ORR) for Cohort A1 was 67%, with 38% achieving very good partial response (VGPR). |
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Response rates were higher in the prior CAR T-cell group (ORR, 73%; VGPR, 55%; n = 11) compared with the prior ADC group (ORR, 60%; VGPR, 20%; n = 10). |
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Adverse events (AEs) were consistent with the known safety profile of cevostamab, with no fatal AEs. |
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All cytokine release events were Grade 1–2 and affected 71% of patients overall (90% who received prior ACD and 55% who received prior CAR T-cell therapy). |
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Cevostamab shows efficacy in heavily pre-treated RRMM patients with prior BCMA-targeted ADC or CAR T-cell exposure, with a clinically manageable safety profile. These findings support further investigation and potential integration of cevostamab into clinical practice for this patient population. |
- Kumar S. Cevostamab in patients with RRMM who are triple-class refractory and have received prior BCMA-targeted or ADC or CAR T-cell: Initial results from the phase I/II CAMMA-2 study. Presentation #S210. Presented at: European Hematology Association 2024 Hybrid Congress; Jun 13–16, 2024; Madrid, ES.
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