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How to sequence BCMA-directed therapies in early relapsed/ refractory multiple myeloma
At the ESH 7th Translational Research Conference:
Multiple Myeloma
with Martin Kaiser, Mohamad Mohty, and Rakesh Popat
Saturday, October 5, 2024 | 09:10-10:10 CEST
Register nowThis independent educational activity is funded by GSK. All content is developed independently by the faculty. The funders are allowed no influence on the content of this activity.
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CAMMA-2 (NCT05535244) is an ongoing phase I/II study evaluating the efficacy and safety of cevostamab (a FcRH5xCD3 bispecific antibody) in patients with relapsed/refractory multiple myeloma (RRMM) who are triple-class refractory and have received a prior BCMA-targeted agent. Analysis of Cohort A1 (n = 21), which enrolled patients with prior exposure to BCMA-targeted antibody–drug conjugate (ADC) or chimeric antigen receptor (CAR) T-cell therapy, was presented at EHA 2024 by Shaji Kumar. |
Key learnings: |
In CAMMA-2, following treatment with cevostamab, the overall response rate (ORR) for Cohort A1 was 67%, with 38% achieving very good partial response (VGPR). |
Response rates were higher in the prior CAR T-cell group (ORR, 73%; VGPR, 55%; n = 11) compared with the prior ADC group (ORR, 60%; VGPR, 20%; n = 10). |
Adverse events (AEs) were consistent with the known safety profile of cevostamab, with no fatal AEs. |
All cytokine release events were Grade 1–2 and affected 71% of patients overall (90% who received prior ACD and 55% who received prior CAR T-cell therapy). |
Cevostamab shows efficacy in heavily pre-treated RRMM patients with prior BCMA-targeted ADC or CAR T-cell exposure, with a clinically manageable safety profile. These findings support further investigation and potential integration of cevostamab into clinical practice for this patient population. |
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