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2024-08-08T13:26:24.000Z

CAMMA-2 Cohort A1: Cevostamab in patients with RRMM and prior BCMA-targeted ADC or CAR T-cell therapy

Aug 8, 2024
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Learning objective: After reading this article, learners will be able to cite a new clinical development in relapsed/refractory MM.

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CAMMA-2 (NCT05535244) is an ongoing phase I/II study evaluating the efficacy and safety of cevostamab (a FcRH5xCD3 bispecific antibody) in patients with relapsed/refractory multiple myeloma (RRMM) who are triple-class refractory and have received a prior BCMA-targeted agent.

Analysis of Cohort A1 (n=21), which enrolled patients with prior exposure to BCMA-targeted antibody–drug conjugate (ADC) or chimeric antigen receptor (CAR) T-cell therapy, was presented at EHA 2024 by Shaji Kumar.  


Key learnings:

In CAMMA-2, following treatment with cevostamab, the overall response rate (ORR) for Cohort A1 was 67%, with 38% achieving very good partial response (VGPR). 

Response rates were higher in the prior CAR T-cell group (ORR, 73%; VGPR, 55%; n=11) compared with the prior ADC group (ORR, 60%; VGPR, 20%; n=10). 

Adverse events (AEs) were consistent with the known safety profile of cevostamab, with no fatal AEs. 

All cytokine release events were Grade 12 and affected 71% of patients overall (90% who received prior ACD and 55% who received prior CAR T-cell therapy). 

Cevostamab shows efficacy in heavily pre-treated RRMM patients with prior BCMA-targeted ADC or CAR T-cell exposure, with a clinically manageable safety profile. These findings support further investigation and potential integration of cevostamab into clinical practice for this patient population. 

  1. Kumar S. Cevostamab in patients with RRMM who are triple-class refractory and have received prior BCMA-targeted or ADC or CAR T-cell: Initial results from the phase I/II CAMMA-2 study. Presentation #S210. Presented at: European Hematology Association 2024 Hybrid Congress; Jun 13–16, 2024; Madrid, ES.   

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