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Ben DermanDuring the 64th American Society of Hematology (ASH) Annual Meeting and Exposition, the Multiple Myeloma Hub was pleased to speak to Benjamin Derman, University of Chicago, Chicago, US. We asked, After ASH 2022, are we closer to using minimal residual disease (MRD)-guided treatment decisions in multiple myeloma (MM)?
After ASH 2022, are we closer to using MRD-guided treatment decisions in MM?
Derman opens by discussing the results of trials presented in ASH abstracts1–4 that consider the theme of MRD-guided de‑escalation of therapy, with a focus on the proportion of patients who remained off-treatment after de-escalation of maintenance therapy, as well as the number with resurgence and progression. Derman concludes by explaining how these combined results allow for better identification of patients who can safely discontinue treatment after an extended period of maintenance therapy and sustained MRD negativity.
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