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On March 24, 2022, it was announced that the European Medicines Agency’s (EMA) Committee for Medicinal Products for Human Use (CHMP) provide a positive opinion for granting a conditional marketing authorization for the use of ciltacabtagene autoleucel (cilta-cel) for the treatment of adult patients with relapsed/refractory multiple myeloma (RRMM). The marketing authorization is for patients who have received at least three prior therapies, including an immunomodulatory agent, a proteasome inhibitor, and an anti-CD38 antibody, and have demonstrated disease progression on the last therapy.1
Cilta-cel is a B-cell maturation antigen (BCMA)-directed chimeric antigen receptor T-cell therapy, which has recently been granted approval by the U.S. Food and Drug Administration (FDA) in this patient population based on results of the CARTITUDE-1 trial. Read more about this here.
Editorial theme | Neurotoxicity and anti-BCMA agents
Chimeric antigen receptor (CAR) T-cell therapy (CAR-T) and bispecific antibodies represent two novel immunotherapeutic treatment modalities in the relapsed/refractory (R/R) setting of multiple...
EHA2022 abstracts: What's hot in multiple myeloma?
To help navigate the exciting content being presented at the EHA2022 Congress, the Multiple Myeloma Hub Steering Committee members have provided their recommendations for the top abstracts to look...
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