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Survival rates for patients with multiple myeloma (MM) have improved over recent years due to the development of targeted therapies, stem cell transplantation, and combination approaches.1 Response to first-line treatment is one of the most important prognostic factors associated with survival in patients with newly diagnosed MM (NDMM).2 The relationship between depth of response and survival has previously been established, however, the impact of time to response on outcomes remains unclear.3
Dr. Nidhi Tandon, from the Division of Hematology, Mayo Clinic, Rochester, US, and colleagues, published findings from a retrospective analysis evaluating the prognostic impact of response time in the front-line therapy setting in 2705 consecutive patients with NDMM, within 90 days of diagnosis.4 Response data after two and four cycles of front-line therapy, and overall best response were assessed in 840 patients. The primary end-point was defined as patients who achieved a very good partial response (VGPR).
In the multivariate analysis, patients were stratified by transplant status to examine the impact of response on survival following adjustment for treatment received.
The authors concluded that the results from this retrospective analysis illustrate the achievement of a deep response following first-line treatment, independent of the time to response, is prognostic for improved long-term outcomes in patients with NDMM.
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