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A prospective observational study to measure health-related quality of life (HRQoL) in patients with relapsed/refractory multiple myeloma (RRMM), was conducted by Xavier Leleu and colleagues from Hopital de La Miletrie, Poitiers, France, and was published in Blood Cancer Journal in March 2017. Currently, there is no cure for RRMM, yet patients have prolonged survival due to improved treatments, and therefore ensuring a high quality of life throughout this treatment journey is paramount. This study was aimed at assessing the impact and burden of treatment on patient Health-related Quality of Life (HRQoL), in real-life context.
This study provided real-world data to show that HRQoL was not significantly affected in patients receiving second- or third- line treatment with either lenalidomide or bortezomib. This provides re-assurance for practitioners using these treatment regimens, as a high quality of life throughout the treatment journey is important. Since the study population was small, the authors noted that repeating this study in a larger population could produce more robust results and provide a better understanding of the overall treatment impact.
Treatment advances for multiple myeloma (MM) that have prolonged survival emphasise the importance of measuring patients' health-related quality of life (HRQoL) in clinical studies. HRQoL/functioning and symptoms of patients with relapsed/refractory MM (RRMM) receiving second- or third-line lenalidomide or bortezomib treatment were measured in a prospective European multicentre, observational study at different time points. At baseline, patients in the lenalidomide cohort were frailer than in the bortezomib cohort with more rapid disease progression at study entry (more patients with Eastern Cooperative Oncology Group performance status >2, shorter time from diagnosis, more chronic heart failure, higher serum creatinine levels, more patients with dialysis required). About 40% of the patients receiving lenalidomide discontinued the study in <6 months while 55% in the bortezomib cohort discontinued. No substantial HRQoL deterioration was observed for the first 6 months in patients with RRMM receiving one or the other treatment. For patients still on treatment at study completion (month 6), only the European Organization for Research and Treatment of Cancer Quality-of-Life Core domains of Diarrhoea and Global Health Status/QoL had worsened in the lenalidomide and bortezomib cohorts, respectively. A clinically meaningful deterioration in HRQoL was more often observed for patients who discontinued the study prior to 6 months in the bortezomib cohort than in the lenalidomide cohort.
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