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Monoclonal gammopathy of undetermined significance (MGUS) is a benign condition that can progress to smoldering multiple myeloma (SMM) and/or multiple myeloma (MM). It is now widely accepted that all patients with MM have had MGUS at some point before onset of the disease.
It has been previously shown that the existence of probands with either MM or MGUS is associated with increased risk of MGUS among first-degree relatives1. However, several studies addressing the correlation between familial MM/MGUS and disease prognosis, have produced contradictory findings.
Alyssa I. Clay-Gilmour from the Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, US, and collaborators, examined the prevalence of MGUS among first-degree family members of patients with MM and SMM, in an expanded cohort of probands from a previous study1. The MGUS prevalence rate was compared with that of a reference population2. Taking into account the probands’ age at disease onset, tumor, and clinical characteristics, they also studied the risk of familial MGUS among first-degree family members. The results were published in Leukemia in September 20183.
This study reveals a 2–3-fold increase in MGUS prevalence among first-degree family members of patients with MM/SMM, in agreement with previously published results. However, it does not support an association between familial MGUS and the age, gender, isotype, or cytogenetics of MM probands. Screening first-degree relatives in families with more than one member affected with MM may be an effective method to prevent disease progression.
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