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The improvements in novel therapeutic approaches have significantly improved the survival rates of patients with multiple myeloma (MM) in recent years.1 However, the presence of pre-existing pulmonary disease may affect treatment availability and survival in patients with MM; with retrospective studies demonstrating patients with MM and lung disease have worse outcomes.2
Associate Professor Georgia Trakada from the National and Kapodistrian University of Athens, Athens, GR, and colleagues, published findings from a prospective non-interventional trial examining the prognostic value of pulmonary function tests (PFTs) in patients with newly diagnosed, symptomatic MM.3 At the time of diagnosis, prior to anti-MM therapy, the lung function of consecutive enrolled patients (n = 121; median age = 67 years; range, 37–90) was evaluated using PFTs. The aim of the study was to assess the association of lung function and outcome over time.
The authors concluded that the results from this first prospective analysis on the prognostic value of pulmonary function assessment in patients with MM demonstrated lung dysfunction independently affects the outcomes of patients with MM. Moreover, the integration of pulmonary function analysis at diagnosis, with consideration of results in the treatment pathway of patients with MM, may allow for further improvements to survival and reduce treatment-related complications.
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