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Measurable residual disease (MRD) negativity is increasingly being investigated and used as a biomarker for treatment cessation in patients with multiple myeloma (MM) who are eligible for transplant.
However, MRD resurgence and progressive disease (PD) are observed in some patients posttreatment cessation guided by MRD-negativity; highlighting the importance of identifying risk factors and predictors of resurgence in this population to prevent disease progression.
Here, we summarize a report published by Guerrero et al.1 in Blood on the predictors of unsustained MRD-negativity in patients with MM who are eligible for transplant.
Figure 1. Hazard ratio for predictors of MRD-resurgence and PD*
CTC, circulating tumor cells; ISS, International Staging System.
*Adapted from Guerrero, et al.1
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