The mm Hub website uses a third-party service provided by Google that dynamically translates web content. Translations are machine generated, so may not be an exact or complete translation, and the mm Hub cannot guarantee the accuracy of translated content. The mm and its employees will not be liable for any direct, indirect, or consequential damages (even if foreseeable) resulting from use of the Google Translate feature. For further support with Google Translate, visit Google Translate Help.
The Multiple Myeloma Hub is an independent medical education platform, sponsored by Bristol Myers Squibb, GSK, Johnson & Johnson, Pfizer, Roche and Sanofi. The levels of sponsorship listed are reflective of the amount of funding given. View funders.
Now you can support HCPs in making informed decisions for their patients
Your contribution helps us continuously deliver expertly curated content to HCPs worldwide. You will also have the opportunity to make a content suggestion for consideration and receive updates on the impact contributions are making to our content.
Find out more
Create an account and access these new features:
Bookmark content to read later
Select your specific areas of interest
View mm content recommended for you
Denosumab edges towards EU approval for MM-related SREs
Amgen’s monoclonal antibody densoumab is edging closer towards approval in the European Union (EU) for the treatment of Multiple Myeloma (MM) patients with Skeletal Related Events (SREs). On 23 February 2018, the Committee for Medicinal Products for Human Use (CHMP) recommended an expansion of the current indication for denosumab, having reviewed recent phase III trial data to assess denosumab in comparison with the currently used drug zoledronic acid (ZA) – see previous MM Hub article.
The study enrolled 1718 Newly Diagnosed (ND) MM patients and indicated a superior progression-free survival (PFS) with denosumab (46.1 months) compared to ZA (35.4 months). Importantly, denosumab led to less renal toxicity (10% vs 17%) in comparison to ZA, which can be nephrotoxic if taken long-term. This, therefore, offers a safer long-term option to MM patients with SREs at risk of developing renal complications, or those already presenting with severe renal damage.
References