Tumor suppressor genes slow down cell division, to allow for the repair of DNA mistakes or induction of apoptosis in case of severe cell damage. Abnormal function of tumor suppressor gene TP53 rarely occurs in early stages of MM. However, the frequency of TP53 alterations increases along with the progression of the disease. They are commonly associated with complex cytogenetics, older age, drug resistance, and poor prognosis. Treating patients with TP53 mutations is a high unmet need.